Systemic Biodistribution and Intravitreal Pharmacokinetic Properties of Bevacizumab, Ranibizumab, and Aflibercept in a Nonhuman Primate Model

Systemic Biodistribution and Intravitreal Pharmacokinetic Properties of Bevacizumab, Ranibizumab, and Aflibercept in a Nonhuman Primate Model

PURPOSE. To determine the intravitreal pharmacokinetic properties and to study the systemic biodistribution characteristics of 1-124-labeled bevacizumab, ranibizumab, and aflibercept with positron emission tomography-computed tomography (PET/CT) imaging in a nonhuman primate model. METHODS. Three gr...

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Bibliographic Details
Main Authors: Christoforidis, John Byron, Briley, Karen, Binzel, Katherine, Bhatia, Prayna, Wei, Lai, Kumar, Krishan, Knopp, Michael Vinzenz
Other Authors: Univ Arizona, Med Ctr, Dept Ophthalmol & Vis Sci
Language:en
Published: ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2017
Subjects:
biodistribution
pharmacokinetics
radiolabeling
positron emission tomography
intravitreal drug delivery
Online Access:http://hdl.handle.net/10150/627123
http://arizona.openrepository.com/arizona/handle/10150/627123

Internet

http://hdl.handle.net/10150/627123
http://arizona.openrepository.com/arizona/handle/10150/627123

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