A dominant-negative mutant inhibits multiple prion variants through a common mechanism
Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless, dominant-negative prion mutants can revert phenotypes associated with some conformations. These observations suggest that, while intervention is possible...
| Main Authors: | , , , |
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| Other Authors: | |
| Language: | en |
| Published: |
PUBLIC LIBRARY SCIENCE
2017
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| Online Access: | http://hdl.handle.net/10150/626074 http://arizona.openrepository.com/arizona/handle/10150/626074 |