Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to similar to 97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (OE) in motor neurons results in decreased...

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Bibliographic Details
Main Authors: Coyne, Alyssa N., Lorenzini, Ileana, Chou, Ching-Chieh, Torvund, Meaghan, Rogers, Robert S., Starr, Alexander, Zaepfel, Benjamin L., Levy, Jennifer, Johannesmeyer, Jeffrey, Schwartz, Jacob C., Nishimune, Hiroshi, Zinsmaier, Konrad, Rossoll, Wilfried, Sattler, Rita, Zarnescu, Daniela C.
Other Authors: Univ Arizona, Dept Mol & Cellular Biol
Language:en
Published: CELL PRESS 2017
Online Access:http://hdl.handle.net/10150/625980
http://arizona.openrepository.com/arizona/handle/10150/625980

Internet

http://hdl.handle.net/10150/625980
http://arizona.openrepository.com/arizona/handle/10150/625980

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