A dynamical framework for complex fractional killing

When chemotherapy drugs are applied to tumor cells with the same or similar genotypes, some cells are killed, while others survive. This fractional killing contributes to drug resistance in cancer. Through an incoherent feedforward loop, chemotherapy drugs not only activate p53 to induce cell death,...

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Bibliographic Details
Main Authors: Ballweg, Richard, Paek, Andrew L., Zhang, Tongli
Other Authors: Univ Arizona, Dept Mol & Cellular Biol
Language:en
Published: NATURE PUBLISHING GROUP 2017
Online Access:http://hdl.handle.net/10150/625501
http://arizona.openrepository.com/arizona/handle/10150/625501