Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results from this study in...

Full description

Bibliographic Details
Main Authors: Dupre, Tess V., Doll, Mark A., Shah, Parag P., Sharp, Cierra N., Siow, Deanna, Megyesi, Judit, Shayman, James, Bielawska, Alicja, Bielawski, Jacek, Beverly, Levi J., Hernandez-Corbacho, Maria, Clarke, Christopher J., Snider, Ashley J., Schnellmann, Rick G., Obeid, Lina M., Hannun, Yusuf A., Siskind, Leah J.
Other Authors: Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol
Language:en
Published: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017
Subjects:
ceramide
sphingolipids
apoptosis
inflammation
Online Access:http://hdl.handle.net/10150/624924
http://arizona.openrepository.com/arizona/handle/10150/624924

Internet

http://hdl.handle.net/10150/624924
http://arizona.openrepository.com/arizona/handle/10150/624924

Similar Items