p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex
Activation of the stress-responsive transcription factor NRF2 is the major line of defense to combat oxidative or electrophilic insults. Under basal conditions, NRF2 is continuously ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for degradation ( t...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Language: | en |
| Published: |
AMER SOC MICROBIOLOGY
2017
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10150/623934 http://arizona.openrepository.com/arizona/handle/10150/623934 |