p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

Activation of the stress-responsive transcription factor NRF2 is the major line of defense to combat oxidative or electrophilic insults. Under basal conditions, NRF2 is continuously ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for degradation ( t...

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Bibliographic Details
Main Authors: Tao, Shasha, Liu, Pengfei, Luo, Gang, Rojo de la Vega, Montserrat, Chen, Heping, Wu, Tongde, Tillotson, Joseph, Chapman, Eli, Zhang, Donna D.
Other Authors: Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol
Language:en
Published: AMER SOC MICROBIOLOGY 2017
Subjects:
KEAP1
NRF2
autophagy
cancer chemoresistance
oxidative stress
p97
proteasome
protein quality control
ubiquitylation
Online Access:http://hdl.handle.net/10150/623934
http://arizona.openrepository.com/arizona/handle/10150/623934

Internet

http://hdl.handle.net/10150/623934
http://arizona.openrepository.com/arizona/handle/10150/623934

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