G-Quadruplex in the NRF2 mRNA 5′ Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress

G-Quadruplex in the NRF2 mRNA 5′ Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress

Inhibition of protein synthesis serves as a general measure of cellular consequences of chemical stress. A few proteins are translated selectively and influence cell fate. How these proteins can bypass the general control of translation remains unknown. We found that low to mild doses of oxidants in...

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Bibliographic Details
Main Authors: Lee, Sang C., Zhang, Jack, Strom, Josh, Yang, Danzhou, Dinh, Thai Nho, Kappeler, Kyle, Chen, Qin M.
Other Authors: Univ Arizona, Coll Med, Dept Pharmacol
Language:en
Published: AMER SOC MICROBIOLOGY 2017
Subjects:
RNA binding proteins
RNA structure
antioxidant genes
protein translation
proteomics
Online Access:http://hdl.handle.net/10150/622753
http://arizona.openrepository.com/arizona/handle/10150/622753

Internet

http://hdl.handle.net/10150/622753
http://arizona.openrepository.com/arizona/handle/10150/622753

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