The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo

The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo

The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute lung injury (ALI). We demonstrate that ectopic expression of a constitutively-active (C/A) MLCP regulatory subunit (MYPT1) attenuates the ability of LPS to increase endothelial (EC) permeability. Dow...

Full description

Bibliographic Details
Main Authors: Kovacs-Kasa, Anita, Gorshkov, Boris A., Kim, Kyung-Mi, Kumar, Sanjiv, Black, Stephen M., Fulton, David J., Dimitropoulou, Christiana, Catravas, John D., Verin, Alexander D.
Other Authors: Univ Arizona, Ctr Lung Vasc Pathobiol
Language:en
Published: NATURE PUBLISHING GROUP 2016
Online Access:http://hdl.handle.net/10150/622686
http://arizona.openrepository.com/arizona/handle/10150/622686

Internet

http://hdl.handle.net/10150/622686
http://arizona.openrepository.com/arizona/handle/10150/622686

Similar Items