Acute systemic DNA damage in youth does not impair immune defense with aging

Acute systemic DNA damage in youth does not impair immune defense with aging

Aging-related decline in immunity is believed to be the main driver behind decreased vaccine efficacy and reduced resistance to infections in older adults. Unrepaired DNA damage is known to precipitate cellular senescence, which was hypothesized to be the underlying cause of certain age-related phen...

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Bibliographic Details
Main Authors: Pugh, Jason L., Foster, Sarah A., Sukhina, Alona S., Petravic, Janka, Uhrlaub, Jennifer L., Padilla-Torres, Jose, Hayashi, Tomonori, Nakachi, Kei, Smithey, Megan J., Nikolich-Žugich, Janko
Other Authors: Univ Arizona, Coll Med, Dept Immunobiol
Language:en
Published: WILEY-BLACKWELL 2016
Subjects:
aging
DNA damage
irradiation
T-cell
vaccination
Online Access:http://hdl.handle.net/10150/622599
http://arizona.openrepository.com/arizona/handle/10150/622599

Internet

http://hdl.handle.net/10150/622599
http://arizona.openrepository.com/arizona/handle/10150/622599

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