Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer

ER positive (ER+) and HER2 negative (HER2-) breast cancers are routinely treated based on estrogen dependence. CDK4/6 inhibitors in combination with endocrine therapy have significantly improved the progression-free survival of patients with ER+/HER2- metastatic breast cancer. Gene expression profil...

Full description

Bibliographic Details
Main Authors: Knudsen, Erik S., Witkiewicz, Agnieszka K.
Other Authors: Univ Arizona, Dept Med
Language:en
Published: IMPACT JOURNALS LLC 2014
Subjects:
Online Access:http://hdl.handle.net/10150/622114
http://arizona.openrepository.com/arizona/handle/10150/622114