Overexpression of BDNF in the ventral tegmental area enhances binge cocaine self-administration in rats exposed to repeated social defeat.

Overexpression of BDNF in the ventral tegmental area enhances binge cocaine self-administration in rats exposed to repeated social defeat.

Stress is a major risk factor for substance abuse. Intermittent social defeat stress increases drug self-administration (SA) and elevates brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area (VTA) in rats. Intra-VTA BDNF overexpression enhances social defeat stress-induc...

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Bibliographic Details
Main Authors: Wang, Junshi, Bastle, Ryan M, Bass, Caroline E, Hammer, Ronald P, Neisewander, Janet L, Nikulina, Ella M
Other Authors: Univ Arizona, Coll Med
Language:en
Published: PERGAMON-ELSEVIER SCIENCE LTD 2016
Subjects:
Brain-derived neurotrophic factor
Social defeat stress
Cocaine self-administration
Nucleus accumbens
deltaFosB
Online Access:http://hdl.handle.net/10150/621303
http://arizona.openrepository.com/arizona/handle/10150/621303

Internet

http://hdl.handle.net/10150/621303
http://arizona.openrepository.com/arizona/handle/10150/621303

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