(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.

Chronic pain affects the life of millions of people. Current treatments have deleterious side effects. We have advanced a strategy for targeting protein interactions which regulate the N-type voltage-gated calcium (CaV2.2) channel as an alternative to direct channel block. Peptides uncoupling CaV2.2...

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Bibliographic Details
Main Authors: Moutal, Aubin, Chew, Lindsey A, Yang, Xiaofang, Wang, Yue, Yeon, Seul Ki, Telemi, Edwin, Meroueh, Seeneen, Park, Ki Duk, Shrinivasan, Raghuraman, Gilbraith, Kerry B, Qu, Chaoling, Xie, Jennifer Y, Patwardhan, Amol, Vanderah, Todd W, Khanna, May, Porreca, Frank, Khanna, Rajesh
Other Authors: Univ Arizona, Coll Med, Dept Pharmacol
Language:en
Published: LIPPINCOTT WILLIAMS & WILKINS 2016
Subjects:
CaV2.2
CRMP2
(S)-lacosamide
Constellation pharmacology
Calcium imaging
Postoperative pain
Neuropathic pain
Online Access:http://hdl.handle.net/10150/621224
http://arizona.openrepository.com/arizona/handle/10150/621224

Internet

http://hdl.handle.net/10150/621224
http://arizona.openrepository.com/arizona/handle/10150/621224

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