Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level
Genetic association analyses of rare variants in next-generation sequencing (NGS) studies are fundamentally challenging due to the presence of a very large number of candidate variants at extremely low minor allele frequencies. Recent developments often focus on pooling multiple variants to provide...
| Main Authors: | , , , |
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| Other Authors: | |
| Language: | en |
| Published: |
Public Library of Science
2016
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| Online Access: | http://hdl.handle.net/10150/618985 http://arizona.openrepository.com/arizona/handle/10150/618985 |