Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.
Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical modeling and with experimental evidence. It was not...
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Language: | en |
| Published: |
NATURE PUBLISHING GROUP
2016
|
| Online Access: | http://hdl.handle.net/10150/618983 http://arizona.openrepository.com/arizona/handle/10150/618983 |