DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lpr mice in vivo

DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lpr mice in vivo

INTRODUCTION:B cells have many different roles in systemic lupus erythematosus (SLE), ranging from autoantigen recognition and processing to effector functions (for example, autoantibody and cytokine secretion). Recent studies have shown that intracellular nucleic acid-sensing receptors, Toll-like r...

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Main Authors: Lenert, Petar, Yasuda, Kei, Busconi, Liliana, Nelson, Patrice, Fleenor, Courtney, Ratnabalasuriar, Radhika, Nagy, Peter, Ashman, Robert, Rifkin, Ian, Marshak-Rothstein, Ann
Other Authors: Departments of Internal Medicine and Pathology, Carver College of Medicine, The University of Iowa, Iowa City, C312GH, 200 Hawkins Drive, IA 52242, USA
Language:en
Published: BioMed Central 2009
Online Access:http://hdl.handle.net/10150/610359
http://arizona.openrepository.com/arizona/handle/10150/610359

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http://hdl.handle.net/10150/610359
http://arizona.openrepository.com/arizona/handle/10150/610359

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