The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines

The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines

PURPOSE: The anti-tumor activity of glucose analogs 2-deoxy-glucose (2-DG) and D-allose was investigated alone or in combination with p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190 or platinum analogs as a strategy to pharmacologically target glycolytic tumor phenotypes. METHODS: Hyp...

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Bibliographic Details
Main Authors: Malm, S. W., Hanke, N. T., Gill, A., Carbajal, L., Baker, A. F.
Other Authors: College of Pharmacy, University of Arizona
Language:en
Published: BioMed Central 2015
Subjects:
2-deoxy-glucose
D-allose
Hypoxia inducible factor 1α
Pancreatic cancer
Ovarian cancer
p38 mitogen activated protein kinase
Online Access:http://hdl.handle.net/10150/610319
http://arizona.openrepository.com/arizona/handle/10150/610319

Internet

http://hdl.handle.net/10150/610319
http://arizona.openrepository.com/arizona/handle/10150/610319

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