Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast

Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast

BACKGROUND: Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine...

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Bibliographic Details
Main Authors: Hermansen, Russell A., Mannakee, Brian K., Knecht, Wolfgang, Liberles, David A., Gutenkunst, Ryan N.
Other Authors: Department of Molecular Biology, University of Wyoming
Language:en
Published: BioMed Central Ltd 2015
Subjects:
Evolutionary systems biology
Metabolic pathway evolution
Phylogenetics
Kinetic model
Enzyme evolution
Substitution rate
Online Access:http://hdl.handle.net/10150/610280
http://arizona.openrepository.com/arizona/handle/10150/610280

Internet

http://hdl.handle.net/10150/610280
http://arizona.openrepository.com/arizona/handle/10150/610280

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