Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer

Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer

BACKGROUND:Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterized by an elevated mutation rate and genomic instability. If a...

Full description

Bibliographic Details
Main Authors: Facista, Alexander, Nguyen, Huy, Lewis, Cristy, Prasad, Anil, Ramsey, Lois, Zaitlin, Beryl, Nfonsam, Valentine, Krouse, Robert, Bernstein, Harris, Payne, Claire, Stern, Stephen, Oatman, Nicole, Banerjee, Bhaskar, Bernstein, Carol
Other Authors: Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Language:en
Published: BioMed Central 2012
Subjects:
"Colon cancer"
"DNA repair"
Pms2
Ercc1
Xpf
Ku86
"Genomic instability"
Cancerization
"Field defect"
Mutation
Online Access:Facista et al. Genome Integrity 2012, 3:3 http://www.genomeintegrity.com/content/3/1/3
http://hdl.handle.net/10150/610153
http://arizona.openrepository.com/arizona/handle/10150/610153

Internet

Facista et al. Genome Integrity 2012, 3:3 http://www.genomeintegrity.com/content/3/1/3
http://hdl.handle.net/10150/610153
http://arizona.openrepository.com/arizona/handle/10150/610153

Similar Items