Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice

Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice

INTRODUCTION:Vascular injury and accumulation of red blood cells in the space of Disse (hemorrhage) is a characteristic feature of acetaminophen hepatotoxicity. However, the mechanism of nonparenchymal cell injury is unclear. Therefore, the objective was to investigate if either Kupffer cells or int...

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Bibliographic Details
Main Authors:	Knight, Tamara, Jaeschke, Hartmut
Other Authors:	Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Language:	en
Published:	BioMed Central 2004
Online Access:	Comparative Hepatology 2004, 3(Suppl 1):S46 http://www.comparative-hepatology.com/content/3/S1/S46 http://hdl.handle.net/10150/610125 http://arizona.openrepository.com/arizona/handle/10150/610125

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