CHARACTERIZATION AND TARGETING OF THE MULTIPLE DNA SECONDARY STRUCTURES IN THE KRAS PROXIMAL PROMOTER TO MODULATE GENE EXPRESSION
KRAS is a well-validated drug target for anti-cancer therapy, yet no clinically useful drugs that directly inhibit its function currently exist. We aim to target KRAS at the transcriptional level, through DNA secondary structures.
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| Language: | en_US |
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The University of Arizona.
2015
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| Online Access: | http://hdl.handle.net/10150/559576 |