DESIGN AND SYNTHESIS OF STRUCTURAL, STEREOISOMERIC AND CONFORMATIONALLY RESTRICTED ANALOGUES OF ALPHA-MELANOTROPIN: COMPARATIVE BIOLOGICAL PROPERTIES ON MELANOPHORES AND MELANOMA CELLS
Several chemically-modified analogues of α-melanotropin (α-MSH, Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂) were prepared by solid-phase peptide synthesis, including [Nle⁴]-α-MSH, Ac-[Nle⁴]-α-MSH₄₋₁₃-NH₂, Ac-[Nle⁴]-α-MSH₁₋₆-NH₂, Ac-α-MSH₇₋₁₀-NH₂, Ac-α-MSH₁₁₋₁₃-NH₂, Ac-[Nle⁴]-α-MSH(,4...
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| Language: | en_US |
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The University of Arizona.
1981
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| Online Access: | http://hdl.handle.net/10150/282076 |