Design, Synthesis, and Biological Evaluation of Novel Chimeric and Cyclic Peptide Ligands Targeting the Human Melanocortin-3 Receptor
In an effort to develop potent and selective agonists and antagonists for the human melanocortin-3 receptor, several new peptide design approaches were employed. This includes peptides featuring a chimeric fusion of the alpha-MSH and AgRP critical pharmacophores, as well as a variety of cyclic ligan...
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| Language: | en |
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The University of Arizona.
2012
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| Online Access: | http://hdl.handle.net/10150/244784 |