Design, Synthesis and Biological Evaluation of c-MYC G-Quadruplex Interactive Agents
The G-quadruplex secondary structure has evolved as a promising anti-tumor target in recent years. This distinctive structure has been proposed to form in the promoter regions of a variety of genes, including the c-MYC oncogene, which is over-expressed in 60% of cancers. The G-quadruplex structure...
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| Language: | EN |
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The University of Arizona.
2006
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| Online Access: | http://hdl.handle.net/10150/194716 |