Studies on the Biosynthesis and Isolation of the Biosynthetic Gene Cluster for the Salinosporamides of the Marine Bacterium Salinospora tropica
Salinosporamide A is a potent inhibitor of the 20S proteasome and has recently entered phase I human clinical trials for the treatment of multiple myeloma. This novel marine natural product is produced by the recently described marine bacterium Salinispora tropica. Salinosporamide A contains an un...
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| Language: | EN |
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The University of Arizona.
2006
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| Online Access: | http://hdl.handle.net/10150/194242 |