Structure-Activity Study of a-N-Methylated SHU9119 Analogues, hMC4R/TNF-a Antagonists, and Mutational Studies of the Melanocyte Stimulating Hormone Receptor

Structure-Activity Study of a-N-Methylated SHU9119 Analogues, hMC4R/TNF-a Antagonists, and Mutational Studies of the Melanocyte Stimulating Hormone Receptor

The human melanocortin receptors (hMCRs) play a fundamental role in human behavior such as satiety, feeding, sexual and more. A set of SHU9119 peptide derivatives were studied for their structure-activity relationships. These peptides contained a sequential a-N-methylation amino acid scan.A second...

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Bibliographic Details
Main Author: Zingsheim, Morgan Robert
Other Authors: Hruby, Victor J.
Language:EN
Published: The University of Arizona. 2009
Subjects:
GPCR
Melanocortin
Melanocyte
Synthetic Peptides
Tumor Necrosis Factor
Online Access:http://hdl.handle.net/10150/193426

Internet

http://hdl.handle.net/10150/193426

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