Calmodulin Binding and Activation of Mammalian Nitric Oxide Synthases

Calmodulin (CaM) is a ubiquitous cytosolic Ca2+-binding protein involved in the binding and regulation of more than three-hundred intracellular target proteins. CaM consists of two globular domains joined by a central linker region. In the archetypical model of CaM binding to a target protein, the...

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Bibliographic Details
Main Author: Spratt, Donald Eric
Language:en
Published: 2008
Subjects:
Online Access:http://hdl.handle.net/10012/3655