Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal

Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal

Heat shock protein 90 (HSP90) is a molecular chaperone protein that protects proteins from degradation, repairs damaged proteins, and assists proteins in carrying out their functions. HSP90 has hundreds of clients, many of which are inflammatory signaling kinases. The mechanism by which HSP90 enable...

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Bibliographic Details
Main Author: Shimp, Samuel Kline
Other Authors: Biomedical Engineering
Format: Others
Language:en_US
Published: Virginia Tech 2017
Subjects:
inflammation
heat shock protein 90
computational models
geldanamycin
17-DMAG
nuclear factor-κB
Online Access:http://hdl.handle.net/10919/77080
http://scholar.lib.vt.edu/theses/available/etd-05142012-164452/

Internet

http://hdl.handle.net/10919/77080
http://scholar.lib.vt.edu/theses/available/etd-05142012-164452/

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