Enantioselective Reaction Development using Chiral Bifunctional Brønsted Acid/Base Organocatalysis and Applications to Target Molecule Synthesis
The Nutlin class of cis-imidazoline small molecule therapeutics has been shown to inhibit the protein-protein interaction (PPI) between the tumor-suppressor protein p53 and MDM2. The more potent enantiomer of Nutlin-3, ()-Nutlin-3 or Nutlin-3a, has long been used to probe the effects of this PPI in...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2015
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-12082015-110505/ |