Optimizing PEG Molecular Weight and Molar Composition for Enhanced In Vivo Pharmacokinetics of a Mixed Micellar siRNA Carrier

Optimizing PEG Molecular Weight and Molar Composition for Enhanced In Vivo Pharmacokinetics of a Mixed Micellar siRNA Carrier

RNA interference (RNAi) by small interfering RNA (siRNA) possesses great promise as a therapeutic for pathologies whose etiology is related to gene overexpression. However, due to the poor pharmacokinetic properties of siRNA, it requires a carrier for in vivo intravenous delivery. Historically, nucl...

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Bibliographic Details
Main Author:	Miteva, Martina
Other Authors:	Craig L. Duvall
Format:	Others
Language:	en
Published:	VANDERBILT 2013
Subjects:	Biomedical Engineering
Online Access:	http://etd.library.vanderbilt.edu/available/etd-12022013-175726/

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