Optimizing PEG Molecular Weight and Molar Composition for Enhanced In Vivo Pharmacokinetics of a Mixed Micellar siRNA Carrier
RNA interference (RNAi) by small interfering RNA (siRNA) possesses great promise as a therapeutic for pathologies whose etiology is related to gene overexpression. However, due to the poor pharmacokinetic properties of siRNA, it requires a carrier for in vivo intravenous delivery. Historically, nucl...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2013
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-12022013-175726/ |