The Myt1 and Ngn3 feed-forward expression loop drives pancreatic islet differentiation in the mouse

In humans, the proper growth and homeostasis of endocrine islets in the pancreas is of great medical importance, in that loss and dysfunction of islet cells result in Type 1 and Type 2 Diabetes Mellitus. One of the major goals of diabetic-related researches is to understand how islets are formed and...

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Bibliographic Details
Main Author: Wang, Sui
Other Authors: Guoqiang Gu
Format: Others
Language:en
Published: VANDERBILT 2009
Subjects:
Online Access:http://etd.library.vanderbilt.edu/available/etd-11262009-124114/