Synthesis of a Porous, Biocompatible Tissue Engineering Scaffold Selectively Degraded by Cell-Generated Reactive Oxygen Species
Biodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic byproducts that trigger an accelerated, autocatalytic degradation mechanism that can create mismatched rates of...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2013
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-11252013-164025/ |