Structural and Mechanistic Observations of the FosX Class of Fosfomycin Resistance Proteins
The objective of this research was to investigate the structure and catalytic mechanisms of the FosX protein class. These enzymes are epoxide hydrolases that disrupt the first step of bacterial cell wall biosynthesis, thereby inactivating the antibiotic fosfomycin. Data presented in this work concer...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2006
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-11212006-082620/ |