Studies toward a unified synthesis of apoptolidinone C and glycosylated variants
The fully glycosylated apoptolidins have been shown to exert nanomolar activity against several cancer cell types (e.g. human lung cancer and glioblastoma cells). This activity is directly correlated with glycosylation state with the aglycone losing its parent activity (> 10 μM, H292 cells, huma...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2017
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-08172017-143439/ |