A Chemical and Systems Approach to Study the Wnt/beta-catenin Pathway
Wnt/β‐catenin signaling plays a critical role in metazoan development, stem cell maintenance, and human disease. The multicomponent β‐catenin destruction complex maintains low cellular β‐catenin in the absence of a signal and becomes inhibited in the presence of a Wnt ligand, allowing β‐catenin leve...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2010
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| Online Access: | http://etd.library.vanderbilt.edu//available/etd-07082010-093358/ |