OVEREXPRESSION OF ADENYLATION DOMAINS FOR THE IDENTIFICATION OF THE BIOSYNTHETIC PATHWAY OF K-26, AN ACE INHIBITING METABOLITE

K-26 is an acidic tripeptide molecule with ACE inhibitory activity. It represents one of three distinct classes of unique phosphonate containing compounds found in nature. Previous work has found that unlike other C-P bond containing compounds, its biosynthetic pathway does not contain the C-P bond...

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Bibliographic Details
Main Author: Sease, Andrea Monique
Other Authors: Brian O. Bachmann
Format: Others
Language:en
Published: VANDERBILT 2009
Subjects:
Online Access:http://etd.library.vanderbilt.edu//available/etd-04062009-180343/