Identification of Host Factors, Including an Epithelial Cell Receptor, Responsible for Clostridium difficile TcdB-Mediated Cytotoxicity
Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause inflammation, fluid secretion, and cell death. Using a gene trap insertion...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2016
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03282016-124039/ |