Oxidation of Cytosine in DNA
The search for active demethylation processes lead to discovery of 5-hydroxymethylcytosine (5hmC) adduct in the mammalian DNA. This lesion is formed post-replicatively by oxidation of 5methylcytosine (5mC) in the presence of TET deoxygenases. Futher oxidation products of TET oxidations, 5-formylcyto...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2014
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03252014-080514/ |