Quinone Metabolites of Environmental Toxins Poison Topoisomerase IIalpha
Topoisomerases play critical roles in maintaining DNA topology during cellular processes such as DNA replication in eukaryotes. Movement of the replication machinery through the double helix induces positive supercoiling ahead of the fork and precatenanes behind it. Because topoisomerase I and II cr...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2007
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03212007-125752/ |