Examination of focal adhesion kinase’s FAT domain structural response to applied mechanical load

Examination of focal adhesion kinase’s FAT domain structural response to applied mechanical load

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase. Activated FAK is crucial to many biological processes, such as cell proliferation, migration, and survival, all of which have been implicated in the progression and development of cancer. Tyrosine 925 is a Src-phosphorylation site that i...

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Bibliographic Details
Main Author: Alotaibi, Talal Eid
Format: Others
Language:English
Published: 2012
Subjects:
Focal adhesion kinase
Focal adhesion targeting domain
Paxillin LD motifs
Y925 phosphorylation
Molecular dynamics
Mechanical load
Helix unfolding
Online Access:http://hdl.handle.net/2152/ETD-UT-2012-05-5296

Internet

http://hdl.handle.net/2152/ETD-UT-2012-05-5296

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