Development of chromogenic cross-linkers and selective gas-phase dissociation methods to assess protein macromolecular structures by mass spectrometry

Development of chromogenic cross-linkers and selective gas-phase dissociation methods to assess protein macromolecular structures by mass spectrometry

Selective gas-phase dissociation strategies have been developed for the characterization of cross-linked peptides and proteins in quadrupole ion trap mass spectrometers. An infrared chromogenic cross-linker (IRCX) containing a phosphotriester afforded rapid differentiation of cross-linked peptides...

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Bibliographic Details
Main Author: Gardner, Myles Winston
Other Authors: Brodbelt, Jennifer S.
Format: Others
Language:English
Published: 2010
Subjects:
Mass spectrometry
Infrared multiphoton dissociation
Cross-linking
Quadrupole ion trap
Photodissociation
Protein cross-linking
Electron transfer dissociation
Ultraviolet photodissociation
Small-interfering RNA
Online Access:http://hdl.handle.net/2152/ETD-UT-2009-12-513

Internet

http://hdl.handle.net/2152/ETD-UT-2009-12-513

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