Synthesis and receptor affinity of 7[beta]-substituted analogs of codeine : total synthesis of 8,14-dihydromorphinandienone alkaloids
A series of morphinan-based compounds inspired by the semi-synthetic opioid metopon have been synthesized. An expedient route from (-)-codeine to the key intermediate, 6,7-a-epoxide has been developed giving access to enantio-enriched analogs. Classical diaxial opening of the a-epoxide has allowed f...
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| Format: | Others |
| Language: | en |
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2014
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| Online Access: | http://hdl.handle.net/2152/24705 |