Cooperative nuclease activity of the Mre11/Rad50/Xrs2 complex and Sae2 during DNA double-strand break repair

Cooperative nuclease activity of the Mre11/Rad50/Xrs2 complex and Sae2 during DNA double-strand break repair

DNA double-strand breaks (DSBs) are lethal in eukaryotic cells if left unrepaired. In Saccharomyces cerevisiae the Mre11/Rad50/Xrs2 (MRX) complex is required for repair of DSBs through homologous recombination and nonhomologous end joining. Although Mre11 complexes exhibit 3'[rightwards arrow]5...

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Bibliographic Details
Main Author: Lengsfeld, Bettina Marie
Format: Others
Language:English
Published: 2014
Subjects:
Double-strand breaks
Homologous recombination
Nonhumologous end joining
Exonuclease activity
Hairpin-capped DNA ends
Online Access:http://hdl.handle.net/2152/23498

Internet

http://hdl.handle.net/2152/23498

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