Design and Synthesis of Novel Sultams: A Family of Non-nucleoside Reverse Transcriptase Inhibitors and Modeling Studies of a Rhodium Catalyst

Design and Synthesis of Novel Sultams: A Family of Non-nucleoside Reverse Transcriptase Inhibitors and Modeling Studies of a Rhodium Catalyst

3-Phenyl-2,3-dihydro-1,2-benzisothiazole 1,1 dioxide (NSC108406), identified as an HIV-1 reverse transcriptase inhibitor, is chosen for lead optimization. A series of analogues are docked using SYBYL FlexiDock into both wild-type (wt) reverse transcriptase (RT) and Tyr181 --> Cys181 (Y181C) RT, f...

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Bibliographic Details
Main Author:	Kafri, Riyam
Published:	Trace: Tennessee Research and Creative Exchange 2007
Subjects:	Organic Chemistry
Online Access:	http://trace.tennessee.edu/utk_graddiss/205

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