Design and Synthesis of Novel Sultams: A Family of Non-nucleoside Reverse Transcriptase Inhibitors and Modeling Studies of a Rhodium Catalyst
3-Phenyl-2,3-dihydro-1,2-benzisothiazole 1,1 dioxide (NSC108406), identified as an HIV-1 reverse transcriptase inhibitor, is chosen for lead optimization. A series of analogues are docked using SYBYL FlexiDock into both wild-type (wt) reverse transcriptase (RT) and Tyr181 --> Cys181 (Y181C) RT, f...
| Main Author: | |
|---|---|
| Published: |
Trace: Tennessee Research and Creative Exchange
2007
|
| Subjects: | |
| Online Access: | http://trace.tennessee.edu/utk_graddiss/205 |