Conservative Tryptophan Mutations in Protein Tyrosine Phosphatase PTP1B and its Effect on Catalytic Rate and Chemical Reaction

Conservative Tryptophan Mutations in Protein Tyrosine Phosphatase PTP1B and its Effect on Catalytic Rate and Chemical Reaction

Protein-tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphorylated tyrosines by a 2-step mechanism involving nucleophilic attack by cysteine and general acid catalysis by aspartic acid. In most PTPs the aspartic acid resides on a flexible protein loop, consisting of about a dozen residue...

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Bibliographic Details
Main Author: Richan, Teisha
Format: Others
Published: DigitalCommons@USU 2017
Subjects:
PTP1B Kinetic Isotope Effect
mutation
WPD loop
Biochemistry
Organic Chemistry
Other Chemistry
Online Access:https://digitalcommons.usu.edu/etd/5584
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=6656&context=etd

Internet

https://digitalcommons.usu.edu/etd/5584
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=6656&context=etd

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