Effects of Ketoconazole on Uterine Weight and on Unbound Serum Estradiol Relative to Vaginal Cornification in Rats
Ketoconazole is a broad-spectrum antifungal with oral activity and is documented to block steroid biosynthesis in fungi and mammals. Estradiol-primed ovariectomized rats lose the estradiol-induced, cornified layer of the vaginal epithelium as a result of ketoconazole treatment. This effect is not ex...
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| Format: | Others |
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DigitalCommons@USU
1990
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| Online Access: | https://digitalcommons.usu.edu/etd/4074 https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=5069&context=etd |