DNA-Protein Cross-Linking by Pyrrolizidine Alkaloids

Pyrrolizidine alkaloids (PAs) are natural plant compounds found in hundreds of plant species worldwide and are reported to have cytotoxic, carcinogenic, antimitotic, and gentotoxic activity. PAs are metabolized by the cytochrome P450 (CYP) sytem to the pyrrole or the N-oxide form. They pyrroles are...

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Bibliographic Details
Main Author: Drew, Gail L.
Format: Others
Published: DigitalCommons@USU 1997
Subjects:
DNA
Online Access:https://digitalcommons.usu.edu/etd/3919
https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=4926&context=etd