Structure and Dynamics of the p53 Transactivation Domain Binding to MDM2 and RPA70
The tumor suppressor protein, p53, is mutated or dysregulated in nearly all human cancers(1). The amino terminal domains are essential for transcriptional activation in stressed cells and play a vital role in cell cycle regulation, apoptosis and senescence. The transactivation (TAD) and proline rich...
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| Format: | Others |
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Scholar Commons
2012
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| Online Access: | http://scholarcommons.usf.edu/etd/4207 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=5403&context=etd |